A common side effect associated with long-term use of glucocorticoids is:

Long-term use of glucocorticoids is commonly associated with hypertension due to their effects on fluid retention and the regulation of electrolyte balance. Glucocorticoids can lead to increased sodium retention and potassium excretion, causing fluid retention, which in turn elevates blood pressure. Additionally, glucocorticoids can increase the sensitivity of blood vessels to vasoconstrictors, further contributing to an increase in blood pressure.

Other common side effects of glucocorticoids, such as hyperglycemia and potential weight gain, are also important but are not included in the options. Hypertension stands out as a particularly prevalent issue among patients on long-term glucocorticoid therapy. Understanding these side effects is crucial for managing patients effectively and mitigating potential complications associated with glucocorticoid use.