A female patient showing hypoglycemia, nausea, muscle weakness, and depression is most likely suffering from?

The symptoms presented by the female patient—hypoglycemia, nausea, muscle weakness, and depression—are indicative of Addison disease, which is adrenal insufficiency caused by inadequate production of cortisol and, in some cases, aldosterone.

In Addison disease, the lack of cortisol can lead to hypoglycemia due to the hormone's role in glucose metabolism; cortisol helps maintain blood sugar levels by facilitating gluconeogenesis and the mobilization of glucose reserves. Additionally, the deficiency of aldosterone leads to disruptions in electrolyte balance, often resulting in muscle weakness. The psychological symptoms such as depression can also be a direct consequence of hormonal imbalances affecting mood and energy levels.

Other potential conditions listed in the choices do not present the same clinical picture. Diabetes insipidus primarily affects water regulation and does not typically cause hypoglycemia or the specifically noted symptoms. Cushing's disease, characterized by excess cortisol, would more likely lead to symptoms such as weight gain, hypertension, and muscle wasting rather than hypoglycemia. Hyperthyroidism could increase metabolism but would not account for the combination of hypoglycemia and the associated symptoms the patient is experiencing.

Thus, the combination of all these symptoms aligns well with a diagnosis of Addison disease.