A patient receiving hydrocortisone has started estrogen hormonal replacement therapy. What is the nurse's best intervention?

In the context of a patient receiving hydrocortisone along with estrogen hormonal replacement therapy, monitoring the patient's blood glucose levels frequently is the most appropriate intervention.

Hydrocortisone, a glucocorticoid, can lead to increased blood glucose levels as a side effect due to its role in carbohydrate metabolism. Estrogen can also influence glucose metabolism and insulin sensitivity. When both medications are administered together, there's a heightened risk of fluctuations in blood glucose levels due to these interactions.

By closely monitoring the patient's glucose levels, the nurse can detect any significant changes early on and intervene appropriately, ensuring the patient's safety and effective management of their condition. This proactive approach is crucial, especially in individuals who may already be at risk of dysglycemia while on these medications.

Therefore, the focus on monitoring blood glucose provides a comprehensive strategy to manage potential side effects of both hydrocortisone and estrogen therapy.