Based on the metabolic action of glucocorticoids, a client who is on long-term glucocorticoid therapy is at risk of developing what disease?

Glucocorticoids are steroids that play a crucial role in various metabolic processes in the body, including glucose metabolism, fat distribution, and bone health. Long-term glucocorticoid therapy can lead to several metabolic effects that predispose individuals to various health issues.

One of the significant risks associated with chronic glucocorticoid use is osteoporosis. Glucocorticoids can inhibit the function of osteoblasts, the cells responsible for bone formation, and can also enhance the activity of osteoclasts, which are involved in bone resorption. Additionally, glucocorticoids can lead to decreased calcium absorption in the intestines and increased renal excretion of calcium, all of which contribute to lower bone density over time. As a result, patients on long-term glucocorticoid therapy are at a higher risk of developing osteoporosis, which can lead to bone fragility and an increased risk of fractures.

While other conditions like diabetes, hypertension, and obesity can also be associated with glucocorticoid therapy, the direct and well-established link between glucocorticoids and bone metabolism makes osteoporosis a primary concern for patients undergoing prolonged treatment with these agents. This makes the risk of developing osteoporosis a critical aspect to monitor