For optimal effectiveness, when should hydrocortisone be taken by a patient with Addison's disease?

Hydrocortisone should be taken before 09:00 each morning for optimal effectiveness in patients with Addison's disease. This timing aligns with the natural circadian rhythm of cortisol secretion in the body, which is typically highest in the early morning. By administering hydrocortisone in the morning, patients can mimic the body’s normal physiology, help to manage their symptoms more effectively, and alleviate the risk of adrenal crisis. This timing also assists in managing the energy levels and overall well-being throughout the day, allowing for a better response to daily activities.