The nurse should instruct a client on daily glucocorticoid therapy to take the medication at which time of day?

Taking glucocorticoids in the early morning closely aligns with the body's natural circadian rhythm, where cortisol levels peak. This timing helps to mimic the physiological secretion of cortisol from the adrenal glands, minimizing potential side effects and maximizing therapeutic efficacy. Administering the medication early in the day can help reduce the risk of insomnia, weight gain, and other side effects often associated with glucocorticoids. Therefore, it is recommended to take these medications during a time when the body's cortisol levels would typically be highest.