To minimize adrenal suppression, when is the best time for a client to take prescribed prednisone?

Taking prednisone in the morning is the best approach to minimize adrenal suppression. This timing aligns with the body's natural circadian rhythm, where cortisol levels—produced by the adrenal glands—are typically highest in the early morning. Administering prednisone in the morning helps mimic this natural pattern, facilitating a smoother transition and reducing the risk of adrenal suppression. Furthermore, morning dosing can potentially minimize side effects such as insomnia, which may occur if the medication is taken later in the day. By aligning medication intake with the body’s biological clock, patients may achieve a more effective and tolerable treatment regimen.