What assessment finding may indicate liver toxicity in a patient taking ketoconazole?

A yellow tint to the patient's skin, known as jaundice, is a classic indicator of liver toxicity. Ketoconazole, an antifungal medication, is metabolized by the liver, and its use can lead to hepatotoxicity, especially at higher doses or with prolonged use. When the liver is unable to effectively process bilirubin, a byproduct of the breakdown of red blood cells, bilirubin accumulates in the bloodstream, leading to the yellowing of the skin and eyes. Therefore, a yellow tint to the skin serves as a key clinical sign that warrants further investigation into liver function and possible discontinuation of the medication.

The other options do not specifically indicate liver toxicity. Increased heart rate can be linked to a variety of factors, including anxiety, dehydration, or other health conditions. Dry skin can occur for various reasons, including hydration levels or other dermatological conditions. Weight gain can be influenced by multiple factors, such as changes in diet, lifestyle, or medications, and does not singularly indicate liver issues in the context of ketoconazole use.