What electrolyte imbalance is commonly associated with adrenal insufficiency?

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Adrenal insufficiency is often associated with high potassium levels, known as hyperkalemia. This condition occurs because the adrenal glands produce insufficient amounts of cortisol and aldosterone. Aldosterone plays a critical role in regulating sodium and potassium levels in the body; it promotes sodium reabsorption and potassium excretion in the kidneys. When there is a deficiency of aldosterone due to adrenal insufficiency, the kidneys are less able to excrete potassium, leading to its accumulation in the blood.

Additionally, cortisol also influences electrolyte balance. Its deficiency can indirectly contribute to impaired renal function and further exacerbate the retention of potassium. Thus, patients with adrenal insufficiency frequently exhibit hyperkalemia, making elevated potassium an important clinical marker in this condition.

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