What indicates a therapeutic response to mitotane therapy?

A therapeutic response to mitotane therapy is indicated by an improvement in the patient’s functional abilities, such as being able to lift more weight than before treatment. Mitotane is primarily used to treat adrenal cancer and works by reducing the production of cortisol, which can help alleviate symptoms associated with excess cortisol production, such as those seen in Cushing's syndrome.

In this context, the ability to lift 10 pounds after previously only being able to lift 5 reflects an increase in strength or physical capability, which can signify effective management of the underlying condition, potentially through reduced cortisol levels and its associated symptoms. Improvements in physical function are strong indicators that the therapy is having the desired effect on the patient's overall health status.

Other options do not accurately reflect therapeutic responses. The development of a fever could indicate an adverse reaction or infection rather than a positive therapeutic outcome. Reporting no changes in symptoms suggests that there is no improvement, which would not signify an effective response to treatment. Elevated cortisol levels would indicate that mitotane is not achieving its intended effect, as the goal of the treatment is to lower cortisol levels in the body.