What is a common side effect of long-term corticosteroid use?

Long-term use of corticosteroids is well-known to lead to osteoporosis, which is a condition characterized by weak and brittle bones. Corticosteroids can interfere with the bone remodeling process by inhibiting the formation of new bone and increasing bone resorption, which can ultimately result in a decrease in bone density. This effect is particularly concerning for patients on prolonged corticosteroid therapy, as they face an increased risk of fractures and other skeletal complications.

In contrast, hypoglycemia is not typically associated with corticosteroid use; rather, corticosteroids can actually cause an increase in blood sugar levels due to their effects on carbohydrate metabolism. Hair loss is also not a well-documented side effect of corticosteroids, and while it may occur, it is not as common or severe as osteoporosis. Bronchoconstriction is generally more related to asthma medications or conditions that require localized treatment in the lungs, rather than a side effect of corticosteroids. Thus, the correct answer reflects a critical and prevalent concern for patients requiring long-term corticosteroid therapy.