What is a potential side effect of excessive fludrocortisone use?

Excessive use of fludrocortisone, a synthetic mineralocorticoid, can lead to fluid retention and subsequently result in edema. Fludrocortisone's primary action is to promote sodium retention and increase the excretion of potassium; thus, it can cause an imbalance in fluid levels within the body when used in excess.

As sodium is retained, water follows, which increases blood volume and can lead to swelling or edema in various tissues. This side effect is particularly relevant in conditions such as congestive heart failure or kidney disease, where fluid balance is already compromised. Monitoring for signs of fluid retention is essential during treatment with fludrocortisone to prevent complications associated with excess fluid in the body.