What is a significant risk associated with incorrect administration of alendronate?

Incorrect administration of alendronate carries a significant risk of esophageal bleeding. Alendronate is a bisphosphonate used primarily to treat osteoporosis and works by inhibiting bone resorption. It is crucial to take the medication with a full glass of water and to remain upright for at least 30 minutes afterwards to ensure proper esophageal transit. If the medication is not taken with adequate water or if the patient lies down immediately after taking it, alendronate can irritate the esophagus, which may lead to inflammation, ulceration, and even serious complications like bleeding.

The risk of esophageal complications is particularly heightened in individuals who have pre-existing esophageal conditions or difficulty swallowing, making adherence to administration guidelines vitally important for safety.