What is the best advice for a patient experiencing nausea when taking ketoconazole?

Taking ketoconazole with food is the best advice for a patient experiencing nausea because food can help to minimize gastrointestinal side effects associated with the medication. Ketoconazole is known to cause nausea in some individuals, and consuming it alongside a meal can enhance the absorption of the drug while also reducing the likelihood of an upset stomach. This is particularly beneficial since ketoconazole is better absorbed in the presence of gastric acid, which food can stimulate.

Additionally, the timing and method of administration with food can create a more tolerable experience for the patient. Encouraging patients to take their medication during or after a meal is a commonly recommended strategy for managing such side effects, ensuring both the effectiveness of the medication and the comfort of the patient.