What is the potential side effect when taking glucocorticoids that the nurse should warn clients about?

When considering the side effects of glucocorticoids, insomnia is a notable potential effect that nurses should inform clients about. Glucocorticoids, such as prednisone, are known to influence the body's metabolism and can disrupt normal sleep patterns, leading to difficulty in falling or staying asleep. This occurs because glucocorticoids can elevate energy levels and alter the body's circadian rhythm, which plays a role in sleep regulation.

Sleep disturbances caused by glucocorticoids can lead to increased fatigue and other associated issues, impacting a client's overall well-being. In contrast, while glucocorticoids can be attributed to increased energy and alertness, this is often temporary and can lead to eventual fatigue. Weight loss is generally not a common side effect; more often, these medications are associated with weight gain. Relief from joint pain can occur due to their anti-inflammatory properties, but it does not represent a side effect that clients would need to be warned about. Therefore, emphasizing the potential for insomnia allows for better management of clients' expectations and overall health during glucocorticoid therapy.