What is the preferred method of administration for desmopressin to ensure effective absorption?

Desmopressin is primarily administered subcutaneously to ensure effective absorption. This method allows the medication to be absorbed into the systemic circulation more efficiently compared to other routes. Subcutaneous administration is beneficial because it bypasses the first-pass metabolism that occurs with oral administration, where the drug is metabolized in the liver before entering the bloodstream, potentially reducing its efficacy. Moreover, subcutaneous injection provides a steady release of the medication, ensuring more consistent therapeutic levels.

While desmopressin can be administered in other ways, such as orally or by inhalation, these routes may not achieve the same level of absorption and efficacy as the subcutaneous route. Intravenous administration can be effective but is not typically preferred in routine settings unless rapid effects are necessary. Overall, the subcutaneous method balances effective absorption with practical administration for patients requiring desmopressin therapy.