What is the primary goal of alternate-day administration of corticosteroids?

The primary goal of alternate-day administration of corticosteroids is to minimize the suppression of normal adrenal function. Corticosteroids exert a negative feedback effect on the hypothalamus and pituitary gland, which in turn can suppress the body's own adrenal production of cortisol. By administering corticosteroids every other day, the drug levels peak and then decline, allowing the adrenal glands some time to recover and produce their own cortisol between doses. This method aims to provide effective therapeutic outcomes while also reducing the risk of long-term adrenal suppression and associated complications that can arise from continuous daily use of corticosteroids.