What is the recommended time for a client to take prednisone to minimize adrenal suppression?

Taking prednisone in the morning is recommended to minimize adrenal suppression. This timing aligns with the body's natural circadian rhythm, which shows that cortisol levels peak in the early morning and decrease throughout the day. When prednisone, a synthetic glucocorticoid, is taken in the morning, it mimics the body’s natural production of cortisol, reducing the risk of adrenal suppression.

Administering the medication at this time also helps to minimize side effects such as insomnia or increased appetite, which can occur when the medication is taken later in the day. This timing supports optimal physiological function and reduces the potential for adverse effects associated with glucocorticoid use. Therefore, the practice of dosing prednisone in the morning is important for maintaining adrenal health while effectively managing conditions that require glucocorticoid therapy.