What is true regarding changes in appearance for patients on glucocorticoid therapy?

Patients undergoing glucocorticoid therapy often experience specific changes in appearance, such as weight gain, moon facies, or skin thinning, which are commonly associated with Cushing's syndrome-like symptoms due to the effects of these medications on metabolism and body processes. When glucocorticoid therapy is tapered off, many of these changes have the potential to improve or reverse, as the body gradually returns to its baseline state without the influence of the extra steroid levels. This reversal can depend on various factors, including the duration of therapy and the individual’s response.

In the context of treatment, while cosmetics may help manage the appearance issues temporarily, they do not address the underlying cause or lead to a true reversal of the changes induced by glucocorticoids. Therefore, the expectation of improvement once therapy is reduced or discontinued makes it clear that the changes can indeed reverse, reinforcing the validity of the chosen answer.