What laboratory values should a nurse monitor due to the black box warning associated with ketoconazole?

Monitoring AST (aspartate aminotransferase), ALT (alanine aminotransferase), and GGT (gamma-glutamyl transferase) is essential when a patient is prescribed ketoconazole due to the potential for hepatotoxicity, which is highlighted in the drug's black box warning. Ketoconazole can cause serious liver damage, and elevated levels of these liver enzymes are indicative of liver dysfunction or injury. By regularly checking these laboratory values, healthcare providers can detect early signs of hepatotoxicity, allowing for prompt intervention if liver damage occurs. This proactive monitoring is crucial for ensuring patient safety while using ketoconazole, making it a fundamental aspect of patient care associated with this medication.