What should the nurse do if a patient receiving hydrocortisone experiences increased wheezing after starting cholestyramine?

In the scenario presented, the appropriate action for the nurse is to hold the cholestyramine medication if the patient receiving hydrocortisone experiences increased wheezing after starting this new drug.

Cholestyramine is a bile acid sequestrant that can interfere with the absorption of various medications, potentially including hydrocortisone, which is crucial for the patient’s condition. The increased wheezing may suggest a respiratory reaction that could be exacerbated by cholestyramine or its interaction with hydrocortisone. Withholding the cholestyramine allows for reassessment of the patient's respiratory status and prevents further exacerbation of potential adverse effects.

Monitoring the patient's response is vital, and if wheezing persists or worsens, alternative treatment strategies can be considered, such as administering a bronchodilator or adjusting the hydrocortisone dosage, depending on the overall clinical picture. Holding the cholestyramine ensures the patient's immediate safety and provides an opportunity to evaluate the impact of this medication on the patient's respiratory status.