What signs or symptoms should a nurse monitor for in a client taking high-dose methylprednisolone for Cushing's syndrome?

In a client taking high-dose methylprednisolone for Cushing's syndrome, monitoring for signs and symptoms associated with excess corticosteroid levels is essential. Methylprednisolone is a synthetic corticosteroid that can mimic the effects of cortisol in the body, which is pertinent in managing conditions like Cushing's syndrome.

Moon face is characterized by a rounded, puffy face that results from fat redistribution, which is common in patients exposed to high levels of glucocorticoids. Buffalo hump refers to the accumulation of fat at the base of the neck, another hallmark sign associated with Cushing's syndrome and prolonged corticosteroid use. Osteoporosis is a serious side effect of long-term corticosteroid therapy, as these medications can lead to decreased bone density over time, increasing the risk of fractures.

Given that all of these signs—moon face, buffalo hump, and osteoporosis—are related to the excessive administration of corticosteroids like methylprednisolone, it is crucial for a nurse to monitor for all of them. Recognizing these manifestations enables early intervention and management to mitigate complications and improve patient outcomes. Therefore, the correct answer encompasses the comprehensive monitoring of these symptoms.