When a client is prescribed hydrocortisone, what is the most important instruction to convey?

Taking hydrocortisone with food is crucial because it helps minimize gastrointestinal discomfort that can occur with corticosteroid use. Corticosteroids, such as hydrocortisone, can irritate the stomach lining, potentially leading to nausea, gastritis, or ulcers if taken on an empty stomach. By taking the medication with food, the impact on the stomach is lessened, which is especially important for individuals who may be sensitive or who have a history of gastrointestinal issues.

Moreover, consistent administration with meals can help improve the absorption and overall effectiveness of the medication. This approach also aids in maintaining stable blood levels of the steroid throughout the day, which can reduce the risk of side effects associated with fluctuating levels. Therefore, advising the client to take hydrocortisone with food provides a safer and more comfortable way to comply with the medication regimen.