Which drug combination with corticosteroids could lead to possible toxic effects?

The combination of corticosteroids with erythromycin can lead to possible toxic effects, specifically related to the metabolism of corticosteroids. Erythromycin is a macrolide antibiotic that can inhibit certain cytochrome P450 enzymes in the liver, particularly CYP3A4. Since many corticosteroids are metabolized by this enzyme, erythromycin can increase the concentration of corticosteroids in the bloodstream, leading to an elevated risk of side effects and toxicity associated with corticosteroid use.

This interaction can be clinically significant, especially in individuals who require long-term corticosteroid therapy, as it may exacerbate the potential for adverse effects such as gastrointestinal bleeding, increased blood glucose levels, or adrenal suppression. Understanding drug interactions is crucial in managing patient safety and ensuring effective treatment outcomes when corticosteroids are prescribed alongside other medications.