Which drug, if combined with corticosteroids, would lead to possible toxic effects?

Combining erythromycin with corticosteroids can lead to notable toxic effects due to erythromycin's interaction with the cytochrome P450 system. This interaction can inhibit the metabolism of corticosteroids, leading to increased serum levels and prolonged effects of the steroids. As a result, patients may experience greater side effects or toxic reactions due to the higher concentrations of corticosteroids in their system.

In contrast, aspirin, ibuprofen, and acetaminophen generally do not influence the metabolism of corticosteroids in a way that would significantly increase the risk of toxicity. While these medications can have their own potential side effects, they do not interact with corticosteroids in a manner that intensifies toxic effects through metabolic inhibition. This understanding highlights the importance of reviewing drug interactions, particularly with agents that are metabolized similarly, to ensure patient safety and effective treatment outcomes.