Which glucocorticoid is also known to have some mineralocorticoid effects?

Hydrocortisone is a glucocorticoid that is also known to have some mineralocorticoid effects. This characteristic makes hydrocortisone distinct among glucocorticoids, as it can influence electrolyte balance and fluid retention, similar to mineralocorticoids like aldosterone. The mineralocorticoid activity is particularly relevant in clinical situations where both glucocorticoid and mineralocorticoid effects may be beneficial, such as in adrenal insufficiency, where maintaining normal blood pressure and electrolyte balance is crucial.

Other glucocorticoids mentioned, such as dexamethasone and betamethasone, primarily exhibit potent anti-inflammatory effects with minimal mineralocorticoid activity, making them less suitable for conditions requiring mineralocorticoid effects. Budesonide, primarily used for its anti-inflammatory properties in respiratory conditions, also lacks significant mineralocorticoid action. Therefore, hydrocortisone stands out as the correct choice due to its dual activity.