Which is a potential side effect associated with glucocorticoid therapy?

Weight gain is a well-documented potential side effect associated with glucocorticoid therapy. Glucocorticoids can cause weight gain through various mechanisms, including increased appetite, alterations in metabolism, and fluid retention. These hormones can influence the body's distribution of fat, often leading to an accumulation of fat in the face, abdomen, and other areas.

This weight gain can be particularly pronounced with long-term use of glucocorticoids, making it a significant concern for both patients and healthcare providers. Monitoring weight and implementing strategies to mitigate weight gain are essential when patients are prescribed glucocorticoid therapy, especially during prolonged treatment.