Which medication is classified as a long-acting glucocorticoid?

Dexamethasone is classified as a long-acting glucocorticoid due to its extended duration of action compared to other glucocorticoids. This medication has a half-life of approximately 36 to 54 hours, which allows for less frequent dosing while maintaining therapeutic effects. Its potent anti-inflammatory and immunosuppressive properties make it a preferred choice for conditions that require sustained glucocorticoid activity, such as in certain autoimmune diseases, severe inflammation, or as part of cancer treatment regimens.

In contrast, hydrocortisone and prednisone are considered to have shorter durations of action and are typically administered more frequently. Triamcinolone, while longer-acting than hydrocortisone and prednisone, does not match the extended action of dexamethasone. Therefore, dexamethasone stands out among the glucocorticoids as the long-acting agent suitable for conditions requiring prolonged therapy.