Which of the following is a potential side effect of corticosteroids?

Corticosteroids are known for their anti-inflammatory and immunosuppressive properties but also for a range of potential side effects due to their pharmacological action. One significant side effect associated with the use of corticosteroids is the development of peptic ulcers.

Corticosteroids can inhibit the production of protective mucus in the stomach lining and promote gastric acid secretion, which can lead to an erosion of the gastrointestinal mucosa. This erosion can result in ulcer formation, characterized by symptoms such as abdominal pain, nausea, and, in severe cases, gastrointestinal bleeding.

Other options presented here are not typically associated with corticosteroid use. For example, hypoglycemia is contrary to the expected metabolic effect of corticosteroids, which often raise blood glucose levels. Weight loss typically occurs with conditions that cause hypercortisolism, whereas corticosteroid therapy often leads to weight gain due to fluid retention and increased appetite. Lastly, bradycardia is not a common side effect of corticosteroids; instead, these agents may lead to elevated heart rates in certain contexts such as stress responses.

Therefore, the association of peptic ulcers with corticosteroid use highlights a critical warning for patients receiving such therapy, emphasizing the importance of monitoring gastrointestinal symptoms during treatment.